Expression of PTHrP in the condyle cartilage after traction of the mandibular ramus and zygomatic arch in rabbits / 实用口腔医学杂志

ABSTRACT

Objective:To understand the roles of PTHrP in the pathogenesis of temporomandibular joint after over mechanical loading. Methods:Fifteen adult New Zealand rabbits were subjected to traction between the mandibular ramus and zygomatic arch in the postero-superior direction unilaterally using elastic force. The rabbits were killed respectively at 2, 4 and 6 weeks and the histologic changes were observed by Hematoxylin & Eosin staining. The expression of PTHrP in the condyle of TMJ was observed by immunohistochemistry. Results:Stronger expression of PTHrP could be found in proliferation cell layers and upper hypertrophy cell layers in the early stage after operation, and weaker expression in mid stage, but stronger near the chondrocyte clusters. Conclusion:It is suggested that PTHrP might relate to the regeneration of condyle cartilage.