Your browser doesn't support javascript.
loading
Preparation and in vitro Release of Metoclopramide Orally Disintegrating Tablets / 中国药师
China Pharmacist ; (12): 1882-1884,1894, 2015.
Artigo em Chinês | WPRIM | ID: wpr-671172
ABSTRACT

Objective:

To prepare and optimize the formula of metoclopramide orally disintegrating tablets, and investigate the in vitro drug dissolution behavior.

Methods:

The formula was optimized by full-factorial experiment design, the ratio of mannotil to micro-crystalline cellulose ( X1 ) and the amount of disintegrating agent ( X2 ,%) were selected as the independent variables, and the friabili-ty ( Y1 ,%) , disintegration time ( Y2 , s) and metoclopramide dissolution ( Y3 ,%) were used as the dependent variables. The release rate of metoclopramide orally disintegrating tablets in different dissolution media was studied.

Results:

The optimum formula of meto-clopramide orally disintegrating tablets was as followsthe ratio of mannotil to microcrystalline cellulose was 2. 5∶ 1, and the amount of disintegrating agent was 6. 5%. The dissolution of metoclopramide orally disintegrating tablets in the different dissolution media was o-ver 80%.

Conclusion:

The formula design is reasonable, the preparation process is feasible and the quality can be controlled.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Pharmacist Ano de publicação: 2015 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Pharmacist Ano de publicação: 2015 Tipo de documento: Artigo