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Changes of CA125 and PIIINP (Procollagen-3-N-terminal Peptide) in Peritoneal Dialysis Patients with Low GDP Solution / 대한신장학회잡지
Korean Journal of Nephrology ; : 118-125, 2005.
Artigo em Coreano | WPRIM | ID: wpr-67227
ABSTRACT

BACKGROUND:

The bioincompatability of the conventional peritoneal dialysis can be partly attributed to the presence of GDPs, which are generated during the heat sterilization. Formation of GDPs can be significantly reduced by the use of multi-chamber bag systems because high concentrated glucose is separated from alkaline lactate. In order to investigate whether multi-chamber bag system can improve the in vivo biocompatibility, we performed a randomized, prospective study comparing the multi-chamber bag system with the conventional PD system, measuring CA125 and PIIINP levels in the effluent dialysates as well as the other clinical and biochemical parameters.

METHODS:

Forty five patients who were stable on CAPD were enrolled randomly assigned to experiment group (n=27), and control group (n=18). Overnight effluent was collected for measurement of CA125 and PIIINP and the other clinical, biochemical parameters were compared including the number of peritonitis, the ultrafiltration volume.

RESULTS:

In patients treated with the multiple chamber bag system, there were significantly higher levels of CA125 and PIIINP from 1 month. No clinical and biochemical parameters influenced on their levels. The incidence of peritonitis or ultrafiltration volume did not differ between the two groups.

CONCLUSION:

Using the low GDP solution resulted in a better preservation of peritoneal mesothelial mass and an improvement of local peritoneal homeostasis, which are supposed to contribute to the biocompatibility of peritoneal dialysis fluid.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Peritonite / Ultrafiltração / Soluções para Diálise / Esterilização / Incidência / Estudos Prospectivos / Diálise Peritoneal / Diálise Peritoneal Ambulatorial Contínua / Ácido Láctico / Glucose Tipo de estudo: Ensaio Clínico Controlado / Estudo de incidência / Estudo observacional / Estudo prognóstico Limite: Humanos Idioma: Coreano Revista: Korean Journal of Nephrology Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Peritonite / Ultrafiltração / Soluções para Diálise / Esterilização / Incidência / Estudos Prospectivos / Diálise Peritoneal / Diálise Peritoneal Ambulatorial Contínua / Ácido Láctico / Glucose Tipo de estudo: Ensaio Clínico Controlado / Estudo de incidência / Estudo observacional / Estudo prognóstico Limite: Humanos Idioma: Coreano Revista: Korean Journal of Nephrology Ano de publicação: 2005 Tipo de documento: Artigo