PPARγ expression by rambutan peel extract in obesity rat model-induced high-calorie diet
Asian Pacific Journal of Tropical Biomedicine
;
(12): 812-817, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-672663
ABSTRACT
Objective:
To monitor the physiological characteristics and genes expression of obesity rat model after rambutan peel extract (RPE) treatment.Methods:
Twenty-four 12-week-old male rats were divided into 4 groups normal, obesity, obesity treated with ellagic acid (O-EA) and obesity treated withRPE30 (O-RPE30). Physiological characteristics were monitored by measuring body weight, calorie intake, size of adipocyte and level of triglyceride. Peroxisome proliferator activated receptorgamma (PPARγ), CCAAT/enhancer-binding proteinsαand fatty acid binding protein 4 (FABP4) expression were observed using immunohistochemistry, western blotting and quantitativeRT-PCR methods.Results:
Body weight gain ofO-EA andO-RPE30 rats were lower than obesity group and size of adipocyte cells were smaller than obesity group (PConclusions:
RPE have anti-obesity activity by inhibiting body weight gain, declining size of adipocyte, decreasing triglyceride,PPARγ expression and mRNA level ofFABP4 gene on obesity rat model.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Asian Pacific Journal of Tropical Biomedicine
Ano de publicação:
2015
Tipo de documento:
Artigo
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