Pathological Analysis of Fatal Malformations From 515 Perinatal Autopsies / 中华围产医学杂志

ABSTRACT

Objective To explore the significance of fatal malformations to the main causes of perinatal death. Methods Autopsy data from 515 perinatal death between 1981.11 to 1999.9 were obtained from the department of pathology, and the distribution of each category of birth defects was analysed. Results One hundred and forty four fatal malformations were collected. The rate of all birth defects among all autopsy was 50.1% in our hospital, and fatal birth defects was 55.8% out of all the malformations. The major birth defects were of heart and great vessal, digestive system, neural system, and respiratory system. Among which, multiple deformity was usually seen among the cases from the obstetric group,including defects of heart and great vessel, neural system, respiratory system and digestive system and the isolated malformations were mostly seen among cases from pediatric group. Conclusions Fatal malformations were still the leading cause of death during perinatal period . The detected rates of defects of the neural system and digestive system were different between autopsy cases from obstetric and pediatric.