A research of poisoning components in plasma and histological changes of rabbits with acute toxicity of aconitum kusnezoffii (草乌) / 中国中西医结合急救杂志

ABSTRACT

Objective To observe the poisoning components in plasma and histological changes of rabbits with acute toxicity of aconitum kusnezoffii (草乌).Methods Eight rabbits were garaged with aconitum kusnezoffii liquor,aconitum poisoning model was reproduced,electrocardiogram (ECG) and blood pressure were recorded,the concentrations of aconitine,hypaconitine and mesaconitine in plasma after 0.5,1, 2,3 and 6 hours were measured,and the pathological changes of heart,liver and cerebral cortex were observed.Results After garage with poisoning liquor,arrhythmias and the declination of blood pressure, presenting a tendency of progressive aggravation [before garage(121.98?16.77)/(110.66?8.78) mm Hg, 1 hour after garage(102.98?8.34)/(90.22?5.85) mm Hg,2 hours after garage(66.81?9.13)/ (53.40?6.32) mm Hg,1 mm Hg=0.133 kPa,all P