ARGININE AND CLONIDINlE TEST ON THE SAME DAY FOR DIFFERENTIATION OF DWARFISM / 中华内分泌代谢杂志

ABSTRACT

Two groups with each of 15 subjects were studied. In Group A arginine and clonidine were administered in one day, and in Group B in two successive days. The serum growth hormone levels were determined with radioimmunoassay. The results showed that the amplitude of the growth hormone peaks was significantly different between normal children, those with short stature of non-pituitary origin and primary pituitary dwarfism. We suggested that the revised method of growth hormone provoking test, i.e. performing the two tests in one day, injecting arginine intravenously and sampling from intravenous catheter is simple, rapid and accurate for the differentiation of short stature due to various causes.