THE INHIBITION OF CELL PROLIFERATION IN CARCINOMA OF LARGE INTESTINE BY TRANSFORMING GROWTH FACTOR-ALPHA / 肿瘤研究与临床
Cancer Research and Clinic
;
(6)1999.
Artigo
em Chinês
| WPRIM
| ID: wpr-674694
ABSTRACT
Objective To observe the inhibition of transforming growth factor-alpha(TGFa) anti-senseoligodeoxynucleotides on the malignant proliferation of HR8348 cell line. Methods Using the TGFa anti-sense oligodeoxynucleotides, composed of 23 and indifferent oligodeoxynucleotides, to affect the HR8348cell. By observing the cell growth inhibiton, 3H-TdR incorporation,mRNA hybridization and the cell cycleanalysis to identify the inhibiting effects of TGFa anti-sense oligodeoxynucleotides and its mechanism.Results TGFa anti-sense oligodeoxynucleotides can Inhibit the proliferation of HR8348 cell, DNA0synthesis,mRNA expression,and defer the transition period of G,/G, phase to S phase. Conclusion TGFaanti-sense oligodeoxynucleotides can inhibit the malignant proliferation of HR8348 cell effectively.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Cancer Research and Clinic
Ano de publicação:
1999
Tipo de documento:
Artigo
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