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Human ?-cells destruction correlates with Fas expression on ?-cells induced by IFN-? and TNF-? / 中国免疫学杂志
Chinese Journal of Immunology ; (12)1999.
Artigo em Chinês | WPRIM | ID: wpr-674724
ABSTRACT

Objective:

To study the effect of increased expression of Fas on the killing of ? cells

Methods:

The level of Fas expression and apoptosis of human ? cells strain (NIT) were detected by FACS

Results:

There is no Fas expression on NIT But Fas expression can detected by culturing NIT with IFN ? and/or TNF ? The apoptosis of NIT induced by sFasL and anti Fas correlates with the level of Fas expression

Conclusion:

Fas expression induced by cytokine may represent a factor for the initiation of ? cells destruction

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Immunology Ano de publicação: 1999 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Immunology Ano de publicação: 1999 Tipo de documento: Artigo