Experimental study on inducing apoptosis of tumour cells by protamine inhibiting angiogenesis / 中国癌症杂志
China Oncology
;
(12)2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-675016
ABSTRACT
Purpose:
To study the therapeutic mechanism through inducing apoptosis of tumour by protamine inhibiting angiogenesis .Methods:
The vascular density and apoptotic index(AI)in the tumour were investigated by immunohistological and Tunel(terminal deoxynucletidy1 transferase-mediated dU TP nick end-labelling) methods in animal tumour model with experimental treatment.Results:
The vascular density of tumour was much lower in controls. Apoptosis appeard in the treated group and AI is (7.67?1.70)%.Conclusions:
Protamine could reduce the vascular density of tumour very much and induce the apoptosis of tumour cells. The therapeutic effects were achieved by inhibiting angiogenesis and inducing apoptosis of tumour.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Oncology
Ano de publicação:
2001
Tipo de documento:
Artigo
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