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Oxaliplation and flurouracil in combination with concurrent radiotherapy for advanced rectal cancer / 中国癌症杂志
China Oncology ; (12)2001.
Artigo em Chinês | WPRIM | ID: wpr-675123
ABSTRACT

Purpose:

To evaluate the effect of oxaliplation (L-OHP)+flurouracil/calcium folinate(5-FU/CF) in combination with concurrent radiotherapy for advanced rectal cancer and to find a more effective way of giving them.Meth- odsChemotherapyL-OHP 130 mg/m~2,iv infusion for 2 hours D_1 combined with calcium folinate 200 mg/m~2 for 2 h ours followed by 5-fluorouracil 300 mg/m~2 for 4h D_1~D_5,repeated every 3 weeks.RadiotherapyThe whole pelvic irradiation DT 50~60Gy/25~30/F(5~6 weeks).

Results:

30 advanced rectal cancer patients entered the study.One patient reached complete response(CR),15 partial response,13 stable disease,and 1 with progression after treatment,The overall re- sponse rate(CR+PR) was 53.3%,the 1-year survival rate was 70% (21/30).The main adverse acute effects were gas- trointestinitis,anemia,neuro-sensory toxicity and irradiation rectitis,bone marrow suppression was mild.

Conclusions:

This approach of therapy could improve the therapeutic effect on advanced rectal cancer.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Oncology Ano de publicação: 2001 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Oncology Ano de publicação: 2001 Tipo de documento: Artigo