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Effect and mechanism study of Chinese herbs in the model of bromocriptine induced aborting rats / 中国免疫学杂志
Chinese Journal of Immunology ; (12)2001.
Artigo em Chinês | WPRIM | ID: wpr-675148
ABSTRACT

Objective:

To study the immunologic and endocrinologic mechanism of Chinese herbs in the treatment of abortion

Methods:

SD rats injected with bromocriptine 0 125 mg/d subcutaneously(sc)during day 6~8 of pregnancy were used as aborting model Uteruses of the rats treated with or without Chinese herbs were taken out at day 12 of pregnancy for counting embryoes and determining mRNA levels of Th1/Th2 type cytokines in decidua by semiquantity RT PCR

Results:

The insufficiency of PRL and P in serum during gestation was related to embryo miscarriage remarkably A predominant Th1 response at the maternal fetal interface is harmful to pregnancy Aborting rate induced by bromocriptine was decreased after treating with Chinese herbs Chinese herbs can increase serum PRL and P , then trigger a predominant Th2 response in the model

Conclusion:

With it's effect of increasing PRL and P in serum and the Th2 bias response at the maternal fetal interface, Chinese herbs can reverse the abortion effect of bromocriptine

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Immunology Ano de publicação: 2001 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Immunology Ano de publicação: 2001 Tipo de documento: Artigo