Inhibition of activation of NF-?B enhanced apoptosis induced by cytosine arabinoside in leukemic cells / 中国癌症杂志
China Oncology
;
(12)2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-675354
ABSTRACT
Purpose:
To explore effects of dexamethasone and vincristine on apoptosis and activation of NF ?B of HL60 n cells induced by cytosine arabinoside (Ara C).Methods:
Apoptosis induced by Ara C in HL60 n cells was analysed by Tunel and DNA electrophoresis. The DNA binding activation of NF ?B of HL60 n cells was determined by electrophoretic mobility shift assay(EMSA).Results:
The apoptosis and activation of NF ?B of HL60 n cells could be induced by Ara C. Dexamethasone 1?mol/L and vincristine 0.1?mol/L increased significantly the apoptosis induced by Ara C (increased by 39.1% and 59.2%, P
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Oncology
Ano de publicação:
2001
Tipo de documento:
Artigo
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