Study of ~1H-and ~(31)P-MRS in rat brain under chronic cerebral ischemia / 中华老年医学杂志

ABSTRACT

Objective To study the biochemical alterations in rat brain under chronic cerebral ischemia by means of 1H and 31 P magnetic resonance spectroscopy (MRS) Methods Chronic cerebral ischemia was induced by permanent bilateral commom carotid artery occlusion (2 VO)in the regions of the hippocampal CA1 area and the whole brain. Results In vivo 1H MRS did not reveal any significant change in the concentrations of N acetyl aspartate (NAA) and Lactate (Lac) in the hippocampal CA1 region 31 P MRS in the whole brain showed an elevation of phosphomonoesters (PME). The ratio of PME/(PME+PDE) was 0 54?0 03 in sham group and 0 69?0 02 in 2 VO group ( P