Influence of ozagre sodium on cerebral ischemic tolerance and expression of nuclear factor-?B in rats / 中华老年医学杂志

ABSTRACT

Objective To investigate the influence of ozagrel sodium (OS) on cerebral ischemic tolerance in rat induced by focal ischemic preconditioning (IPC) and on expression of nuclear factor ?B (NF ?B) in rats Methods Fourty five rats were divided into 3 groups The animals were subjected to 2 h middle cerebral artery occlusion (MCAO) 3 days after 10 min IPC, IPC+OS and sham surgery (SS) respectively. After 22 h reperfusion, the rats were killed and the infarct volume, brain water content and NF ?B immunoreactivity were compared among 3 groups. Results Compared with IPC+ MCAO group, there were a furtber decrements in farct volume (93 75?13 40 vs 130 92?14 59, P