Meta-analysis on the association of HLA-DQ polymorphism and type 1 diabetes mellitus in Chinese population / 中华内分泌代谢杂志

ABSTRACT

Objective To evaluate the relationship between genetic polymorphism of HLA DQ and type 1 diabetes mellitus (DM) in Chinese population. Methods Odds ratios (OR) of HLA DQ allele (genotype, haplotype) distributions in patients with type 1 DM against healthy controls were analysed. All the relevant studies were identified, poor qualified studies were excluded and the publication bias was evaluated. The Meta analysis software (REVMAN 4.2) was applied for investigating heterogeneity among individual studies and for summarizing all the studies. Results DQA1*0301, DQA1*0501, DQB1*0201, DQB1*0303, DQB1*0401 and DQB1*0604, were the risky alleles (all P