Your browser doesn't support javascript.
loading
Immunohistochemical Assessment of Peripheral Squamous Lung Cancer: Comparison to Central Squamous Cell Carcinoma and Peripheral Adenocarcinoma
Journal of Lung Cancer ; : 99-102, 2009.
Artigo em Coreano | WPRIM | ID: wpr-67589
ABSTRACT

PURPOSE:

Incidence of peripheral squamous cell carcinoma (pSCCs) of the lung has increased over recent years, but the immunohistochemical factors involved in pSCCs have not been well established. The aim of this study was to analyze the immunohistochemical differences between pSCCs and central-type SCCs (cSCCs), and similarities between pSCCs and peripheral adenocarcinomas (pADCs). MATERIALS AND

METHODS:

In this retrospective study, we investigated the expression of three potential prognostic factors (p53, Ki-67, t-CEA), and two potential therapeutic targets (epidermal growth factor receptor [EGFR], and c-erbB-2) in 263 surgically resected cases of primary SCC and pADCs of the lung from January 2001 to July 2008. We divided the SCCs between peripheral and central types, and compared the expression rates of markers between pSCCs and cSCCs, and between pSCCs and pADCs.

RESULTS:

In this study, there were 149 pADC cases, and among the 114 SCC cases, there were 41 pSCCs (36.0%). There were significantly higher expression rates of Ki-67 and EGFR in pSCCs than in cSCCs or pADCs (p=0.003, p=0.039, respectively).

CONCLUSION:

We found immunohistochemical differencies in pSCCs from cSCCs and pADCs.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Carcinoma de Células Escamosas / Adenocarcinoma / Incidência / Estudos Retrospectivos / Pulmão / Neoplasias Pulmonares Tipo de estudo: Estudo de incidência / Estudo observacional / Estudo prognóstico Idioma: Coreano Revista: Journal of Lung Cancer Ano de publicação: 2009 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Carcinoma de Células Escamosas / Adenocarcinoma / Incidência / Estudos Retrospectivos / Pulmão / Neoplasias Pulmonares Tipo de estudo: Estudo de incidência / Estudo observacional / Estudo prognóstico Idioma: Coreano Revista: Journal of Lung Cancer Ano de publicação: 2009 Tipo de documento: Artigo