A Serine12Stop mutation in PB1-F2 of the 2009 pandemic (H1N1) influenza A: a possible reason for its enhanced transmission and pathogenicity to humans
Journal of Veterinary Science
;
: 349-351, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-67598
ABSTRACT
As the scientific community scrambles to define the ancestry and lineages of the eight segments of new pandemic H1N1 strain, we looked for unique genetic events in this virus's genome to explain the newly found enhanced virulence and transmissibility among humans. Genome annotations of this virus identified a stop mutation replacing serine at codon 12 (S12Stop) of the PB1-F2 protein, a virulence factor in influenza A viruses. Here, we discuss the significance of this finding and how it may contribute to host specialization, explaining the virtual absence of the H1N1 influenza A virus strain in pig populations. This finding is expected to lead to a better understanding of the transmission and pathogenesis of the 2009 pandemic strain.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteínas Virais
/
Virulência
/
Dados de Sequência Molecular
/
Regulação Viral da Expressão Gênica
/
Sequência de Aminoácidos
/
Influenza Humana
/
Vírus da Influenza A Subtipo H1N1
/
Interações Hospedeiro-Patógeno
/
Mutação
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Veterinary Science
Ano de publicação:
2009
Tipo de documento:
Artigo
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