The expression of endogenous TGF-?1 of rabbit pericranium during osteogenesis induced by rhBMP-2 / 中华创伤杂志
Chinese Journal of Trauma
;
(12)2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-676103
ABSTRACT
Objective To study the effect of exogenous rhBMP-2(recombinant human bone morpho- genetic protein-2)on the expression of endogenous TGF-?1 during osteogenesis in rabbits.Methods After successfully duplicating experimental rabbit skull defect model,we detected and analyzed the expression of en- dogenous TGF-?1 of the pericranium in different stages by using immunohistochemieal method in both the ex- perimental group and the control group.Results In the experimental group a lot of mesenchymal cells with positive expression of endogenous TGF-?1 of the pericranium aggregated in duramater in the early stage after operation,and the expression level increased rapidly with the differentiation of mesenchymal cells,and reached the peak at 17,19 day postoperation.Positive cell number of TGF-?1 of pericranium was statistically analyzed in both groups at 7,15,21 days,showing significant difference(t-test,P<0.01 ).Conclusion Exogenous rhBMP-2 can induce and enhance the expression of endogenous TGF-?1 during osteogenesis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Chinese Journal of Trauma
Ano de publicação:
2003
Tipo de documento:
Artigo
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