PASSIVE IMMUNIZATION AGAINST PSEUDOMONAS AERUGINOSA SEPSIS: AN EXPERIMENTAL STUDY / 解放军医学杂志

ABSTRACT

Human and horse polyvalent immune serum and immune globulin were used to control experimental pseudomonas aeruginosa sepsis in burned and unburned mice. The results indicated that the survival rates for the human immune preparations ranged from 70-85.7%; and that for the horse immunoglobulin ranged from 71.4-90% Furthermore, surviving mice showed a shortening of clinical course with rapid abatement of symptoms and signs. The,survival rate was 14.8-20% in untreated control groups, and most of the mice died in 1-4 days after, infection.It is therefore believed that this immunological approach is an efficacious adjunctive measure in controlling life-threatening infection caused by pseudo-monas aeruginosa.