Changes of endothelin and atrial natriuretic peptide in rats of chronic hypoxic pulmonary hypertension / 第二军医大学学报

ABSTRACT

To observe the changes of endothelin(ET) and atrial natriuretic peptide(ANP) lev-els in chronic hypoxic pulmonary hypertensive rats and discuss their mechanism. Methods: We duplicatedthe models of chronic hyp0xic pulmonary hypertensive rats and tested the concentrations of ET and ANP ofplasma and cardiac tissue by radioimmunoassey. Results: In pulmonary hypertension group, plasma ET,plasma ANP and myocardial ET levels increased more significantly than those of controls,except that my-ocardial ANP concentration decreased. There were positive c0rrelati0ns between plasma ET level and plas-ma ANP level and between plasma ET level and myocardial ET level, but a negative correlation betweenplasma ANP level and myocardial ANP level. C0nclusion It is suggested that the synthesis and secretionof ET and ANP increase in pulmonary hypertension,and therefore provides reference to clinical diagnosisand therapy.