Effects of dialyzed membrane on TGF-?1 and MCP-1 plasma levels in hemodialysis patients / 中华肾脏病杂志

ABSTRACT

Objective To investigate effects of different dialyzed membrane on transforming growth factor(TGF-?1 ) and monocyte chemoattractant protein(MCP-1 ) plasma levels in maintenance hemodialysis (MHD) patients. Methods The plasma concentrations of TGF-?1 and MCP-1 were measured by ELISA assay in well-matched uremic patients undergoing maintenance hemodialysis with either cuprophane (CU, n = 27 ) or polysulfone (PSU, n = 25 ). Results Compared with controls (50. 2 ? 5. 7 ng/ml), the patients on CU(82. 9 ? 9. 8 ng/ml) and PSU (65. 5 ? 6. 5 ng/ml)membranes dialysis had significantly higher mean TGF-?1 concentration (P