Inhibitory and excitatory effects of sodium nitroprusside on supraopticnucleus neurons in vitro / 中国临床药理学与治疗学

ABSTRACT

Aim To realize the regulatory actions of nitric oxide(NO) on supraoptic nucleus (SON)neurons by observing the effects of NO donor sodium nitroprusside(SNP) on SON neurons.Methods The cell electrophysioloical properties were obtained by the intracellular recording techniques from the SON neurons in adult rat hypothalamic slices.Results In 11 silent cells, superfusion of SNP(1 mmol?L-1) for 3～5 min resulted in the depolarization response with a decrease of membrane resistance and time constant(P