EFFECTS OF TAURINE AND HIGH FAT DIET ON DMBA INDUCED MAMMARY TUMOR IN RATS / 营养学报

ABSTRACT

Objective: To investigate the anticancer action of taurine and its potential mechanisms. Methods: 101 weanling female SD rats were randomly divided into four groups. They were(1)control group (CL)fed a basic diet;(2)high fat group(HF)fed a high fat diet (10% lard);(3)taurine group (Tau)fed a taurine diet (5% taurine);(4)taurine and high fat group(TH)fed a mixed diet (5%taurine and 10% lard). 10mg DMBA were given to each rat by gavage at age of 6 weeks. Then the rats were fed assigned diet for 26 weeks. By 5 weeks after DMBA administration the rats were palpated once weekly and the time, size, location of each tumor were recorded. The examinations made at the end of experiment were listed below CI, LTT, serum antibody, SOD, MDA, GSH Px, TC, TG, LDL C. Results: The tumor incidence in group HF rats was higher than that in group CL, Tau and TH rats (P