The effect of enteral nutrition on gut barrier in patients with hepatic dysfunction / 肠外与肠内营养

ABSTRACT

Objectives:To determine if enteral nutrition can protect the gut barrier in patients with damaged hepatic function and draw the clinical significance from it. Methods:76 patients whose hepatic function was in Child B or C grade were randomly assigned in enteral nutrition group(EN,30 cases),total parenteral nutrition group(TPN,26 cases) and control group(CON,20 cases).They were given with different nutritional support. Nutritional parameter and hepatic function indexes were massured at the day before operation,5th day and 10th day after the operation respectively.The concentrations of lactulose(L) and Mannitl(M) were detected in the urines with pulsed electrochemical detection(HPLC PED) and the L/M ratio was calculated. Results:No significant differences of hepatic function changes were observed between EN group and TPN group.It was the earlist that EN group reached the positive nitrogon equilibrium among the 3 groups and the loss of body weight after operation was the lowest in EN group There wes no change in L/M ratio in EN group, but the change was significant in TPN group( P