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Effect of clarithromycin on pharmacokinetics of aminophylline at steady state in rabbits / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics ; (12)2000.
Artigo em Chinês | WPRIM | ID: wpr-677653
ABSTRACT

AIM:

To investigate the effect of oral clarithromycin on serum concentrations of aminophylline at steady state and its pharmacokinetics in New Zealand rabbits.

METHODS:

The serum concentration of aminophylline was determined by FPIA in rabbits given(po) aminophylline or aminophylline combined with clarithomycin. The experiment was divided into 2 stages (Ⅰ)the subjects only received a four day course of oral aminophylline until steady state;(Ⅱ)aminophylline and clarithromycin were coadministrated from the d 5 to d 10. The dose of aminophylline was 30 mg?kg -1 and the dose of clarithromycin was 50 mg?kg -1 for each rabbit. The two series of pharmacokineticis parameters were tested by statistic analysis. RESAULTS There was no significant variation in pharmacokinetic parameters between two stages.

CONCLUSION:

It is not necessary to change the therapeutic dose of aminophylline when the drug is taken in combination with clarithromycin.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Clinical Pharmacology and Therapeutics Ano de publicação: 2000 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Clinical Pharmacology and Therapeutics Ano de publicação: 2000 Tipo de documento: Artigo