Blood perfusion-independent neuroprotection induced by antiplatelet agents and its gender-difference / 中国药理学通报

ABSTRACT

AIM To investigate antiplatelet agents induced neuroprotection, which is blood perfusion independent, and its gender difference. METHODS Population spike amplitude (PSA) was measured during hypoxia and posthypoxic recovery in blood fsee hippocampal slices from untreated control mice and from in vivo pretreated mice with a single intraperitoneal injection of acetylsalicylic acid (ASA), ticlopidine or clopidogrel. Extracellular recordings and NADH fluorescence spectroscopy were used to determine PSA and NADH fluorescence upon hypoxia in CA1 region in hippocampal slices from ASA treated male and female mice. RESULTS Posthypoxic recovery of PSA was 25 9%?11 6% in control slices. In slices pretreated with ASA, ticlopidine and clopidogrel PSA recovered to 74 7%?35 7% ( P