Reverse effect of losartan on myocardial fibrosis and left ventricular hypertrophy in treatment of essential hypertensive patients / 中国临床药理学与治疗学

ABSTRACT

AIM: To investigate the effects of losartan on myocardial fibrosis and left ventricular hypertrophy in hypertensive patients. METHODS: 35 essential hypertensive patients with left ventricular hypertrophy were treated with losartan 50-100 mg for 6 mon. Before and after the treatment, serum procollagen typeⅢ (PCⅢ), laminin (LN), and hyaluronic acid (HA) were measured by radioimmunoassay; and left ventricular mass index (LVMI) was determined with ultrasonic cardiogram. RESULTS: After treatment with losartan the serum levels of PCⅢ, LN, HA, and LVMI were all decreased (P