Antioxidant effect of scutellarin and its antagonistic action on the liver toxicity of Se in rats / 中国药理学通报

ABSTRACT

AIM To explore the antagonistic effect of scutellarin on the liver toxicity of upper limit intake (UL) of Se. METHODS Chemical luminescence was used to determine the scavenging effect of scutellarin on reactive oxygen species (ROS) induced by Na 2SeO 3 in vitro . MDA content, the activities of SOD, CAT, GSH Px and histopathological sections were measured to investigate the effects of scutellarin on Se toxicity in rats. RESULTS In vitro experiment showed the ability of scutellarin to inhibit the generation of ROS effectively. MDA content was significantly decreased, the activities of SOD, CAT and GSH Px were significantly increased and liver injury was alleviated obviously in the UL Se plus scutellarin group as compared to the only UL Se group. CONCLUSION Scutellarin markedly antagonized the liver toxicity of UL Se through scavenging ROS induced by excess Se.