Effects of ovariectomy on the expression of estrogen receptor beta immunoreactivity in the basal forebrain of adult female mice / 第三军医大学学报

ABSTRACT

Objective To study the effect of ovarian estrogen on the expression of estrogen receptor beta (ER beta) of the basal forebrain of mice. Methods Ovariectomized (OVX) mice were used as animal model, and nickel ammonium sulfate intensified immunohistochemical SP technique was used to detect the changes of ER beta expression in the basal forebrain. Results The expression of ER beta in the basal forebrain of mice decreased dramatically, after OVX decreased to the lowest levels at 3 d after OVX, increased gradually, and recovered to normal level 20 d later. Conclusion Ovarain estrogen can regulate the expression of ER ? of the murine basal forebrain, indicating that estrogen, via ER ?, can regulate the nerous structure and function of the basal forebrain, which may be the mechanism of estrogen replacement therapy on Alzheimer′s brain.