Effects of Panax notoginseng saponin on macrophage inflammatory protein-1? and monocyte chemoattractant protein-1 in plasma in rats with pulmonary fibrosis / 第三军医大学学报

ABSTRACT

Objective To investigate the effects of Panax notoginseng saponin (PNS) on macrophage inflammatory protein 1?(MIP 1?) and monocyte chemoattractant protein 1(MCP 1) in plasma in rats with pulmonary fibrosis. Methods The dynamic changes of the contents of MIP 1?and MCP 1 in plasma were determined with ELISA. Results The contents of MIP 1? and MCP 1 in plasma were significantly higher in PF group than those in PNS group at most time points(125 pg/ml and 298 pg/ml), and correlated with the development of fibrosis. The contents of MIP 1? and MCP 1, close to those in the control group, were inhibited obviously in PNS group. Conclusion PNS may have effect on the prevention and cure of fibrosis by minimization of the alveolar inflammation due to the effective inhibition of the contents of MIP 1? and MCP 1 in plasma.