Dosage regimen design of intravenous bolus injection administration of two-compartment model based on Microsoft EXCEL / 中国临床药理学与治疗学

ABSTRACT

AIM: To establish a calculation of dosage regimen design on multiple dosing intravenous bolus injection administration of two compartment model. METHODS: Microsoft EXCEL was used to write a program by the pharmacokinetic parameters to show the dosage regimen. RESULTS: The e table displayed maximum dose (D max ) and minimum dose (D min ) of the administration after inputting parameters (?, ?, K 21 and V 1) ,dosing interval (T s), maximum toxic concentration(MTX) and minimum effective concentration(MEC). After inputting maintenance dose and cycle number (n), the e table displayed plasma concentration at any time after the administration, including C (n,s) max and C (n,s) min , fractional number of reaching plateau, loading dose and accumulating time when the plasma concentration was above MEC in Ts or a cycle interval. CONCLUSION: This design method can provide safe and effective dosage regimen for clinical administration.