The effect of sodium orthovanadate on sugar absorption of small intestine in rats / 中国药理学通报

ABSTRACT

AIM To observe the effect of sodium orthovanadate on glucose and maltose absorption and to reveal its mechanism. METHODS ① Normal Wistar rats were divided into 6 groups at random, 0 9% NaCl group, acarbose group(30 mg?kg -1 ) and sodium orthovanadate high dose(16 mg?kg -1 ), middle dose (4 mg?kg -1 ) and low dose (1 mg?kg -1 )groups. The values of blood glucose of all the groups were measured with oxidation enzyme method after administration of glucose and maltose. ② The ? glucosidase was abstracted from the upper small intestine and the inhibitory effect of sodium orthovanadate on ? glucosidase was examined. RESULTS ① Sodium orthovanadate could delay the peak values of plasma glucose induced by glucose, with AUC in these groups lower than that in controls, that is (8 42?0 63) mmol?h -1 ?L -1 ( P