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Enhancement effect of propofol on binding function of GABA_A receptor / 第二军医大学学报
Academic Journal of Second Military Medical University ; (12)2001.
Artigo em Chinês | WPRIM | ID: wpr-678557
ABSTRACT

Objective:

To investigate the influence of propofol on the binding function of GABA A receptor.

Methods:

By using radioligand receptor binding assay, effects of propofol on the specific binding of 3H GABA and saturation curves of GABA A receptor were observed in cortical membrane preparations from mouse cerebral cortex.

Results:

Specific binding experiments showed that propofol at the concentrations of 10 300 ?mol/L markedly enhanced the specific binding of 3H GABA( P 0.05).

Conclusion:

Clinical concentrations of propofol can enhance the binding function of GABA A receptor through increasing the affinity of the low affinity binding site of GABA.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Academic Journal of Second Military Medical University Ano de publicação: 2001 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Academic Journal of Second Military Medical University Ano de publicação: 2001 Tipo de documento: Artigo