Cytokine networks and signal pathways in regulating hemopoietic stem cell proliferation and differentiation / 第二军医大学学报

ABSTRACT

All types of blood cells are derived from a common precursorthe hematopoietic stem cell.Hematopoietic stem cells can be found in different locations of the developing vertebrate organism. Hematopoiesis is a dynamic process sustained by cytokine induced production and activities of hematopoietic stem and progenitor cells.A number of different cytokines,cells,and cytokine cell interactions are involved in regulating the hematopoiesis. Some cytokines have more than one functions partially due to their actions on different target cells.These actions are mediated through specific receptors transmiting intracellular signals.These signals give the stem and progenitor cells critical information to survive,proliferate, differentiate or to migrate. This paper is to review recent developments in some of the major signal transduction pathways influencing hematopoietic growth and differentiation with a particular emphasis on myeloid cells.