MITOCHONDRIAL DNA MICROSATELLITE INSTABILITY AND EXPRESSION OF Bcl-2 AND Bax mRNA IN GASTRIC CANCER AND ITS PRECANCEROUS LESIONS / 解放军医学杂志

ABSTRACT

Objective To explore the relationship between mitochondrial DNA microsatellite instability(mtMSI) and expression of Bcl 2 and Bax mRNA in gastric cancer and its precancerous lesions. Methods mtMSI and expressions of Bcl 2 and Bax mRNA were detected with PCR SSCP and RT PCR. Results Expressions of Bcl 2 mRNA in intestinal metaplasia (IM,53 3%) and dysplasia (Dys, 70%) were significantly higher than that in normal control(10%, P