Treatment of lung cancer with malignant pleural effusion using intrathoracic injection of BCG-PSN combined with mitomycin and cisplatin / 第三军医大学学报

ABSTRACT

Objective To evaluate the efficacy and safety of the intrathoracic injection of polysachride nucleic acid fraction of Bacillus Calmette Guerin(BCG PSN) combined with mitomycin and cisplatin for the treatment of lung cancer with malignant pleural effusion. Methods A total of 53 lung cancer patients with malignant pleural effusion were randomly divided into two groups BCG PSN combined with chemotherapy group (treatment group, 27 patients) and simple chemotherapy group (control group, 26 patients). Drugs were injected into thoracic cavity, which was repeated every 7 day interval. Effective rate, Karnofsky score and toxicities were evaluated. Results After treatment, the effective rate was 88.8% in treatment group and 53 9% in the control group. Significant difference was found in the two groups( P