A Case of Scedosporium apiospermum Keratitis Confirmed by a Molecular Genetic Method / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 307-311, 2008.
Artigo
em Coreano
| WPRIM
| ID: wpr-67869
ABSTRACT
A 54-yr-old male, who was treated by chemotherapy for gastric cancer 15 months ago, presented to Yongdong Severance Hospital, Seoul, with complaints of pain in his right eye caused by a foreign body from the ground in the previous week. He had been treated with topical and oral antibacterial in addition to antifungal agents, but did not show significant clinical improvement. After a positive corneal culture with mold, topical amphotericin B was added to the initial regimen. The mold was identified as Scedosporium apiospermum by macroscopic and microscopic morphologies and the nucleotide sequences of a fungal PCR product showing 99% homology with those of S. apiospermum (EF151349). He recovered with good results at 25 days after corneal epithelial debridement. The early diagnosis of S. apiospermum keratitis is very important for proper treatment. It is recommended that molecular diagnostic methods such as fungal PCR and sequencing be done with conventional cultures whenever a fungal infection is suspected.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Infecções Oculares Fúngicas
/
Anfotericina B
/
Reação em Cadeia da Polimerase
/
Análise de Sequência de DNA
/
Córnea
/
Scedosporium
/
Quimioterapia Combinada
/
Ceratite
/
Antibacterianos
/
Antifúngicos
Tipo de estudo:
Estudo prognóstico
/
Estudo de rastreamento
Limite:
Humanos
/
Masculino
Idioma:
Coreano
Revista:
The Korean Journal of Laboratory Medicine
Ano de publicação:
2008
Tipo de documento:
Artigo
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