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Therapeutic effects of rhein on experimental diabetic nephropathy in rats / 第三军医大学学报
Journal of Third Military Medical University ; (24)1983.
Artigo em Chinês | WPRIM | ID: wpr-678801
ABSTRACT
Objective To investigate the therapeutic effects of rhein on experimental diabetic nephropathy in rats. Methods Rat model of diabetic mellitus was established by interperitoneal injection of streptozotocin (50 mg/kg) . Renal damages and changes of endothelin (ET) in urine and renal tissues were observed at 12 weeks after the induction of diabetic mellitus and after treatment with rhein (70 mg/kg). Results Compared with the normal rats, at 12 weeks after hyperglycemia, diabetic rats had decreased renal weight/body weight(RW/BW), significantly increased mean glomerular plane area (MGPA), mean glomerular volume (MGV), creatinine clearance rate (Ccr), blood urea nitrogen (BUN), and 24 hour urinary protein excretion (UPE) ( P

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Journal of Third Military Medical University Ano de publicação: 1983 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Journal of Third Military Medical University Ano de publicação: 1983 Tipo de documento: Artigo