Related factors and mechanism of impaired glucose tolerance in human with sepsis / 肠外与肠内营养

ABSTRACT

Objectives: To study the related factors and mechanism of the impaired glucose tolerance(IGT) in human with sepsis. Methods: According to the results of intravenous glucose tolerance test, forty patients were classified into two groups 16 control subjects and 24 IGT subjects. The counterregulatory hormone, the basal levels of plasma insulin, glucagons, cortisol, IL 6 and TNF ? were compared in two groups, and the change of inflammatory cytokine and counterregulatory hormone after dextrose infusion were observed. Results: The severity of the disease (APACHEⅡscore, Sepsis score), mixed infection and bacteremia were significantly related to the results of glucose tolerance test( P