The immunopathogenesis of viral hepatitis and its implications in developing new anti-hepatitis drug / 中国药理学通报

ABSTRACT

Immune mediated liver injury plays a key role in the immunopathogenesis of viral hepatitis and autoimmune hepatitis. The phathogenesis of liver injury involved various kinds of cells including lymphocytes, mononuclear macrophages (Kupffer cells), endothelial cells, stallete cells and liver parenchymal cells. Activation of lymphocytes is the initial step of liver damage, and then that the liver macrophages and NK cells. Crosstalk between these cells expands the damage of liver tissues. Cytokines produced by CD8 + cytotoxic T lymphocytes (CTLs) and CD4 + Th cells and other inflammatory cells lead to the persistent infection and liver injury of patients. To protect hepatocytes against cytopathic effect induced by invalid immune response will provide further insight into the development of new anti hepatitis drugs.