The relationship between polymorphisms of NRAMP1 gene and susceptibility to tuberculosis in Chinese Han nation / 中华传染病杂志
Chinese Journal of Infectious Diseases
; (12)2001.
Article
em Zh
| WPRIM
| ID: wpr-679142
Biblioteca responsável:
WPRO
ABSTRACT
Objective To elucidate the relationship between polymorphisms of NRAMP1 gene and susceptibility to tuberculosis in Chinese Han nation by case control study. Methods We selected 127 patients with active pulmonary tuberculosis who were all Han people with mean age of 52.5 years and 58 ethnically matched healthy controls. We typed the polymorphisms of NRAMP1, INT4 and D543N, through polymerase chain reaction restriction fragment length polymorphism (PCR RFLP) techniques. Results Two NRAMP1 polymorphisms were both significantly associated with smear positive pulmonary tuberculosis. Subjects who were heterozygous for polymorphisms in INT4 and D543N were related with tuberculosis. It was the cooperation of different polymorphisms of NRAMP1 that led to the susceptibility to tuberculosis. Conclusions The polymorphisms in NRAMP1 gene affect susceptibility to tuberculosis in Han people in China.
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1
Índice:
WPRIM
Tipo de estudo:
Observational_studies
Idioma:
Zh
Revista:
Chinese Journal of Infectious Diseases
Ano de publicação:
2001
Tipo de documento:
Article