The Genetics of Obstructive Sleep Apnea-hypopnea Syndrome / 医学研究杂志

ABSTRACT

The obstructive sleep apnea-hypopnea syndrome(OSAHS)is considered as a complex genetic disorder with high mor- bidity and mortality.More and more evidence indicate that it has familial aggregation and genetic predisposition.Some gene phenotypes related to upper airway anomalies,abnormal breathing control,obesity,hypertension and insulin resistance might act to increase suscepti- bility to OSAHS.This article reviews current knowledge about a genetic approach to the causes and risk factors for sleep apnea.