Clinical observation of treating acute cerebral infarction by edaravone combined with Ganglioside GM_1 / 中国实用内科杂志

ABSTRACT

Objective To evaluate collaborative effect of the combination with edaravone and ganglioside GM1 (GM1) in treatment of acute cerebral infarction.Methods Factorial design was adopted in the study.All 71 patients with acute cer- ebral infarction were divided into the general treatment group(treated routinely by Compound Salvia Mihiorrhiza Bunge In- jection and aspirin)18 eases,the edaravone group(treated by edaravone and the general treatment)17 case,the GM_1 group (treated by GM_1 and the general treatment)18 cases,the combined treatment group(treated by edaravone and GM1 and the general treatment)18 cases.NIHSS score and Barthel Index(BI) score were recorded before treatment and after treat- ment.Results edaravone and GM_1 reduced NIHSS score of patients with acute cerebral infarction respectively(edaravoneF=12.36,P