EXPERIMENTAL STUDY OF THE PROTECTIVE EFFECT OF FOLIC ACID ON LIVER DAMAGE INDUCED BY ALCOHOL / 解剖学报

ABSTRACT

68 NIH Mice (24-25g) were divided into three groups. Group A was normal control, group B was treated with 54% alcohol in the beverages 0.25ml/per day, and group C was administrated 54% alcohol mixed with folic acid 0.25ml/per day. The histochemical reaction and ultrastructural changes in liver were observed. The reaction of glycogen (PAS reaction), Mg-ATPase SDH LDH G-6-Pasc and ACP was demonstrated respectively by Chayen's, Wachstein-Meisel, Lojda, Bancroft's method, and some procedures of these techniques were modified. The results showed that under the protection effect of acid folic, the regularities seemed to be present in the changes of the following histochemical reactions in the liver cells of the group C (treaded by acid folic) the PAS reaction and the activities of Mg-ATPase SDH LDH G-6-Pase were similar to the group A and apparently higher than that in group B. The activities of ACP were lower those in group B(P