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The Prognostic Significance of Fascin Expression in Colorectal Carcinoma
Intestinal Research ; : 117-125, 2010.
Artigo em Inglês | WPRIM | ID: wpr-68091
ABSTRACT
BACKGROUND/

AIMS:

Fascin, an actin-bundling protein found in membrane ruffles, microspikes, and stress fibers, induces membrane protrusions and increases cell motility in normal and various transformed cells. The expression of fascin in epithelial neoplasms has only been described recently, and the role of fascin in colorectal carcinoma (CRC) is still unknown.

METHODS:

Paraffin sections of CRC from 79 patients were immunohistochemically investigated using monoclonal anti-fascin antibody. Staining of >5% of tumor cells was recorded as positive immunoreactivity.

RESULTS:

Overall, fascin immunoreactivity was detected in 63 of 79 patients (79.7%). Twenty-three patients were classified as 1+ (5-25% immunoreactive tumor cells) and 24 were 2+ (>25% immunoreactive tumor cells). In these patients, 16 had 3+ (>75% immunoreactive tumor cells) fascin immunoreactivity. Fascin immunoreactivity was increased according to the TNM stage (P<0.001), positive lymph node metastasis (P<0.001), budding (P<0.001), vessel invasion (P=0.001), perineural invasion (P=0.039), overall survival (P=0.012), and disease-free survival (P=0.016); however, fascin immunoreactivity was not correlated with recurrence or depth of tumor invasion.

CONCLUSIONS:

This study suggests that an increased expression of fascin was associated with a poor prognosis and the immunohistochemical detection of fascin provides useful information as one of the prognostic values in CRC.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Parafina / Prognóstico / Recidiva / Imuno-Histoquímica / Neoplasias Colorretais / Proteínas de Transporte / Movimento Celular / Neoplasias Epiteliais e Glandulares / Intervalo Livre de Doença / Fibras de Estresse Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Intestinal Research Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Parafina / Prognóstico / Recidiva / Imuno-Histoquímica / Neoplasias Colorretais / Proteínas de Transporte / Movimento Celular / Neoplasias Epiteliais e Glandulares / Intervalo Livre de Doença / Fibras de Estresse Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Intestinal Research Ano de publicação: 2010 Tipo de documento: Artigo