Protective effect and pharmacological ischemic preconditioning of sasanquasaponin mediated by NO on intact rat heart / 中草药

ABSTRACT

Object To study the protective effect and pharmacological ischemic preconditioning of sasanquasaponin (SQS) on intact rat heart and its relationship with NO Methods A model of rat myocardial ischemia induced by sc injection of isoproterenol (ISO) was prepared, and after the administration of selective NO synthesis inhibitor methylene blue (MET), the ECG, serum creatine kinase (CK) activity, free fatty acid (FFA) and adenosine contents were determined Results Preconditioning iv injection of SQS can effectively protect the myocardium from ischemia induced by ISO The cardio protective effect was significantly attenuated when the NO synthesis inhibitor MET were injected prior to SQS Conclusion SQS can effectively protect myocardium ischemia induced by ISO and the protection is most likely to be mediated by NO