EFFECTS OF IN UTERO EXPOSURE OF TCDD ON SYNTHESIS OF EPIDERMAL GROWTH FACTOR AND EPIDERMAL GROWTH FACTOR RECEPTOR IN SUBMANDIBULAR GLAND OF RAT OFFSPRINGS / 解剖学报
Acta Anatomica Sinica
; (6)1954.
Article
em Zh
| WPRIM
| ID: wpr-682020
Biblioteca responsável:
WPRO
ABSTRACT
Objective To study the effect of in utero exposure of TCDD on synthesis of EGF and EGFR in submandibular gland of rat offspring. Methods SD rats were treated with TCDD 5??g/kg on Day 15 of gestation, the expression of EGF and EGFR in submandibular gland of rat offspring were analyzed by immunohistochemistry method. Results On PND32 and PND49, the expression of EGF and EGFR in TCDD experiment group were more than that of control group, the difference was statistically significant.Conclusion In utero exposure of TCDD can promote the synthesis of EGF and EGFR in submandibular gland of rat offspring from prepuberty stage through puberty stage. [
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Índice:
WPRIM
Idioma:
Zh
Revista:
Acta Anatomica Sinica
Ano de publicação:
1954
Tipo de documento:
Article