AN ULTRASTRUCTURAL STUDY ON EFFECT OF HYPOXIC PULMONARY VASCULAR IN YOUNG RATS BY HEME-OXYGENASE/CARBON-MONOXIDE SYSTEM / 解剖学报

ABSTRACT

Objective To explore the effect of hemeoxygenease/carbon monoxide system on hypoxic pulumonary vascular structural remodeling. Methods Twenty six Wister rats were randomly divided into four groupscontrol groups( n =6),hypoxia group( n =7),hypxia+ZnPP group( n =6) and hypoxia+CO group( n =7).Pulmonary artery mean pressure(mPAP) of each rat was elaluated by using right cardiac catheterization,the ultrastructaral changes in intra acinar pulmonary muscularized arteries were observed. Results mPAP was significantly increased in hypoxic rats(22?2 31?mmHg)as compared with that of normal controls(16 57?2 51mmHg)( P