Protective effect of Feikang Granules on endodermis scathe of pulmonary vascular in rats with hypoxia-induced pulmonary hypertension / 中成药

ABSTRACT

Objective: To investigate the protective effect of Feikang Granules (FK) on endodermis scathe of pulmonary vascular in rats with hypoxia induced pulmonary hypertension (HPH). Methods: Hypoxia with intravenous injection FeCl 3 was used to establish model rats with HPH. Hypoxia rats were treated with FK for seven days after hypoxia everyday. Plasma endothelin (ET), superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione peroxidase (GSH PX) in serum were inspected. Results: (1) Those indexes were higher remarkably than control group and showed that the level of series enzyme concerned with oxidation reaction was in unbalance. Pulmonary hypertension and endodermis scathe of pulmonary vascular had happened. (2) The level of ET, MDA, SOD and GSH PX decreased significantly in the treated group. It indicated that FK could inhibit HPH and improve the pathological changes such as endodermis scathe, the unbalance of series enzyme concerned with oxidation reaction. Conclusion:Feikang Granules may partly prevent the development of HPH and endodermis scathe of pulmonary vascular.